Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AN-3485
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

1213827-99-6

1213827-99-6 structure

1213827-99-6 structure

Name: AN-3485
Chemical Name: AN-3485
CAS Number: 1213827-99-6
Molecular Formula: C₁₄H₁₃BClNO₃
Molecular Weight: 289.52
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2019-02-25 11:31:36
Modify Date: 2024-01-02 09:26:13
AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

Name	AN-3485

Description	AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
Target	IC50：AN-3485 inhibits TLR2-, TLR3-, TLR4-, and TLR5-mediates TNF-a, IL-1b, and IL-6 release with IC50 values of human PBMCs (103±68 nM, 68±63 nM, 72±33 nM)and isolated monocytes (77±26 nM; 18±6.7 nM; 32±6.5 nM) [1] .
References	[1]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46.

Molecular Formula	C₁₄H₁₃BClNO₃
Molecular Weight	289.52