1808113-09-8

1808113-09-8 structure

Name: Corin
Chemical Name: Corin
CAS Number: 1808113-09-8
Molecular Formula: C₂₆H₂₈N₄O₂
Molecular Weight: 428.53
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2019-02-12 15:46:57
Modify Date: 2024-01-13 18:01:40
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.

Name	Corin

Description	Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Cancer
Target	IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)[1].
In Vitro	Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC50 95 nM vs. MS-275 EC50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM)[1].
References	[1]. Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53.