1940206-71-2
1940206-71-2 structure
- Name: Dot1L-IN-2
- Chemical Name: Dot1L-IN-2
- CAS Number: 1940206-71-2
- Molecular Formula: C27H24N8O
- Molecular Weight: 476.53
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2019-02-09 08:38:28
- Modify Date: 2024-01-15 11:18:17
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Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively.
| Name | Dot1L-IN-2 |
|---|
| Description | Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.4 nM (Dot1L)[1] Ki: 0.08 nM (Dot1L)[1] |
| In Vitro | Dot1L-IN-2 is a potent, selective Dot1L inhibitor, with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. Dot1L-IN-2 potently inhibits H3K79 dimethylation (IC50, 16 nM), and blocks the activity of the HoxA9 promoter (IC50, 340 nM) in cellular systems. Dot1L-IN-2 also dramatically suppresses proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50, 128 nM)[1]. |
| References |
| Molecular Formula | C27H24N8O |
|---|---|
| Molecular Weight | 476.53 |