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1026987-94-9

1026987-94-9 structure
1026987-94-9 structure
  • Name: DUPA(OtBu)-OH
  • Chemical Name: DUPA(OtBu)-OH
  • CAS Number: 1026987-94-9
  • Molecular Formula: C23H40N2O9
  • Molecular Weight: 488.57
  • Catalog: Research Areas Cancer
  • Create Date: 2019-03-02 08:53:03
  • Modify Date: 2024-01-02 21:20:34
  • DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
Name DUPA(OtBu)-OH
Description DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
Related Catalog
In Vitro DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent[1]. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells[2].
In Vivo DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice[3].
References

[1]. Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selectiveprostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.

[2]. Lv Q, et al. Prostate-Specific Membrane Antigen Targeted Therapy of Prostate Cancer Using a DUPA-Paclitaxel Conjugate. Mol Pharm. 2018 May 7;15(5):1842-1852.

[3]. Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specificmembrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80.
Molecular Formula C23H40N2O9
Molecular Weight 488.57

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title: CAS No. 1026987-94-9 | Chemsrc address: https://www.chemsrc.com/en/baike/1556073.html

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