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Product Name: (+)-Dihydrexidine hydrochloride
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158704-02-0

158704-02-0 structure

158704-02-0 structure

Name: (+)-Dihydrexidine hydrochloride
Chemical Name: (+)-Dihydrexidine hydrochloride
CAS Number: 158704-02-0
Molecular Formula: C₁₇H₁₈ClNO₂
Molecular Weight: 303.78
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2019-02-09 09:32:48
Modify Date: 2024-01-02 20:59:29
(+)-Dihydrexidine hydrochloride is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.

Name	(+)-Dihydrexidine hydrochloride

Description	(+)-Dihydrexidine hydrochloride is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	EC50: 72±21 nM (Dopamine D1 receptor)[1]
In Vitro	(+)-Dihydrexidine hydrochloride (DHX) is a high-potency, bioavailable D1 dopamine receptor agonist. (+)-Dihydrexidine is screened for activity against 40 other binding sites, and is inactive (IC50 greater than 10 microM) against all except D2 dopamine receptors (IC50=130 nM) and alpha 2 adrenoreceptors (IC50=230 nM). Dihydrexidine competes stereoselectively and potently for D1 binding sites in rat striatal membranes labeled with [3H]SCH23390 with an IC50 of about 10 nM compared to about 30 nM for the prototypical D1 agonist SKF38393[2].
In Vivo	To examine the functional state of striatal neurons in response to D1 receptor activation, AC5+/+ and AC5-/- mice are injected with the D1 agonist (+)-Dihydrexidine (30 mg/kg, i.p.) and obtained the dorso-lateral striatum and NAc, separately, 45 min later for RT-PCR analysis. These experiments reveal that (+)-Dihydrexidine -triggered induction of the immediate early genes, c-fos, egr-1, and junB, in the NAc is markedly enhanced in AC5-/- mice compared with that in AC5+/+ mice, while the induction in the dorso-lateral striatum is suppressed in AC5-/- mice[3].
Animal Admin	Mice[3] AC5-/- mice are backcrossed to the C57BL/6J strain for 9 or 10 generations to obtain heterozygote N9 or N10 mice. Mice are treated with (+)-Dihydrexidine (30 mg/kg, i.p.)[3].
References	[1]. Lewis MM, et al. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitizationdissociates from both receptor occupancy and functional potency. J Pharmacol Exp Ther. 1998 Jul;286(1):345-53. [2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. [3]. Kim KS, et al. Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. J Neurochem. 2008 Oct;107(1):105-15.

Molecular Formula	C₁₇H₁₈ClNO₂
Molecular Weight	303.78