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1401728-56-0

1401728-56-0 structure
1401728-56-0 structure
  • Name: GPR4 antagonist 3
  • Chemical Name: GPR4 antagonist 3
  • CAS Number: 1401728-56-0
  • Molecular Formula: C24H28N6O
  • Molecular Weight: 416.52
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2019-03-03 10:22:07
  • Modify Date: 2024-01-14 15:13:26
  • GPR4 antagonist 3 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM[1]. Anti-inflammatory activities[1].

Name GPR4 antagonist 3
Description GPR4 antagonist 3 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM[1]. Anti-inflammatory activities[1].
Related Catalog
Target

IC50: 70 nM (GPR4)[1].

In Vivo GPR4 antagonist 3 shows a significant anti-inflammatory effect in the rat antigen induced arthritis model after oral administration at 30 mg/kg bid[1].GPR4 antagonist 3 also prevents angiogenesis in the mouse chamber model as well as pain as demonstrated in the rat complete Freund’s adjuvant model[1].
References

[1]. Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60(9):3672-3683.

Molecular Formula C24H28N6O
Molecular Weight 416.52