2097887-20-0
2097887-20-0 structure
- Name: MM-589
- Chemical Name: MM-589
- CAS Number: 2097887-20-0
- Molecular Formula: C28H44N8O5
- Molecular Weight: 572.70
- Catalog: Research Areas Cancer
- Create Date: 2019-03-03 10:26:14
- Modify Date: 2024-01-03 12:29:30
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MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
| Name | MM-589 |
|---|
| Description | MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1] |
| In Vitro | MM-589 (0.01-10 µM) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1]. |
| In Vivo | MM-589 has excellent microsomal stability in human, mouse, and rat microsomes[1]. |
| References |
| Molecular Formula | C28H44N8O5 |
|---|---|
| Molecular Weight | 572.70 |