2152628-33-4

2152628-33-4 structure

Name: Selpercatinib (LOXO-292)
Chemical Name: Selpercatinib
CAS Number: 2152628-33-4
Molecular Formula: C₂₉H₃₁N₇O₃
Molecular Weight: 525.60
Catalog: Research Areas Cancer
Create Date: 2019-03-03 16:46:13
Modify Date: 2024-01-13 09:57:27
Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2].

Name	Selpercatinib

Description	Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 14.0 nM (RETWT), 24.1 nM (RETV804M), 530.7 nM (RETG810R)[1]
References	[1]. Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1. [2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 32, No. 4, 2018.

Molecular Formula	C₂₉H₃₁N₇O₃
Molecular Weight	525.60