313254-94-3

313254-94-3 structure

Name: MMG 11
Chemical Name: MMG-11
CAS Number: 313254-94-3
Molecular Formula: C₁₅H₁₄O₇
Molecular Weight: 306.27
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2019-03-30 13:00:34
Modify Date: 2024-01-02 15:52:38
MMG-11 is a potent and selective human TLR2 antagonist. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with an IC50 of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses[1].

Name	MMG-11

Description	MMG-11 is a potent and selective human TLR2 antagonist. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with an IC50 of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
Target	TLR2
References	[1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160.