887375-15-7
887375-15-7 structure
- Name: (S)-Mapracorat
- Chemical Name: (S)-Mapracorat
- CAS Number: 887375-15-7
- Molecular Formula: C25H26F4N2O2
- Molecular Weight: 462.48
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2019-03-30 14:41:34
- Modify Date: 2024-01-09 16:04:41
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(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
| Name | (S)-Mapracorat |
|---|
| Description | (S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. |
|---|---|
| Related Catalog | |
| In Vitro | (S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM. |
| In Vivo | Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. |
| References |
| Molecular Formula | C25H26F4N2O2 |
|---|---|
| Molecular Weight | 462.48 |