1703748-89-3

1703748-89-3 structure

Name: Fosnetupitant (Pronetupitant)
Chemical Name: Fosnetupitant
CAS Number: 1703748-89-3
Molecular Formula: C₃₁H₃₅F₆N₄O₅P
Molecular Weight: 688.598
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2019-08-07 21:39:02
Modify Date: 2024-01-11 08:21:15
Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].

Name	Fosnetupitant

Description	Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated[1].
In Vivo	Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats[1].
References	[1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.