Fosnetupitant (Pronetupitant)

Modify Date: 2024-01-11 08:21:15

Fosnetupitant (Pronetupitant) structure	Common Name	Fosnetupitant (Pronetupitant)
	CAS Number	1703748-89-3	Molecular Weight	688.598
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₅F₆N₄O₅P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Fosnetupitant (Pronetupitant)

Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].

Name	Fosnetupitant

Description	Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated[1].
In Vivo	Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats[1].
References	[1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.

Molecular Formula	C₃₁H₃₅F₆N₄O₅P
Molecular Weight	688.598
Exact Mass	688.224915
LogP	1.86

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Product Name: Fosnetupitant Chloride
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