2095244-54-3

2095244-54-3 structure

Name: SNIPER(BRD)-1
Chemical Name: SNIPER(BRD)-1
CAS Number: 2095244-54-3
Molecular Formula: C₅₃H₆₆ClN₉O₈S₂
Molecular Weight: 1056.73
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-06-01 18:42:44
Modify Date: 2024-01-09 14:36:35
SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

Name	SNIPER(BRD)-1

Description	SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4 cIAP1:6.8 nM (IC50) cIAP2:17 nM (IC50) XIAP:49 nM (Ki) SNIPER
References	[1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

Molecular Formula	C₅₃H₆₆ClN₉O₈S₂
Molecular Weight	1056.73