1245734-61-5
1245734-61-5 structure
- Name: TK05
- Chemical Name: TK05
- CAS Number: 1245734-61-5
- Molecular Formula: C31H25ClN2O5
- Molecular Weight: 540.99
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Gutathione S-transferase
- Create Date: 2019-06-01 17:17:50
- Modify Date: 2024-01-05 17:46:59
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TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].
| Name | TK05 |
|---|
| Description | TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 95 nM (Leukotriene C4 synthase)[1] |
| In Vitro | TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1]. |
| In Vivo | TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. Animal Model: Zymosan A induced peritonitis mouse model[1] Dosage: 0.12 mg/kg; 6 mg/kg Administration: Given i.p.; only once Result: 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A. |
| References |
| Molecular Formula | C31H25ClN2O5 |
|---|---|
| Molecular Weight | 540.99 |