1706777-46-9

1706777-46-9 structure

Name: Zidebactam sodium salt
Chemical Name: Zidebactam sodium salt
CAS Number: 1706777-46-9
Molecular Formula: C₁₃H₂₀N₅NaO₇S
Molecular Weight: 413.38
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2019-06-01 12:55:28
Modify Date: 2024-01-20 17:58:34
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].

Name	Zidebactam sodium salt

Description	Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.26±0.06 μg/mL (P. aeruginosa PAO1 PBP2)[2].
In Vitro	Zidebactam sodium salt (WCK-5107 sodium salt) inhibits WT Enterobacteriaceae with a MIC50 of 0.25 mg/L[1].Zidebactam sodium salt (WCK-5107 sodium salt) alone exhibits variable activity when tested against E. coli (MIC50/90 0.12/0.12 mg/L) and Enterobacter spp. (MIC50/90 0.12/0.25 mg/L)[1].
References	[1]. Sader HS, et al. WCK 5222 ( cefepime/zidebactam ) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703. [2]. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6).