2243076-67-5

2243076-67-5 structure

2243076-67-5 structure

Name: ZXH 3-26
Chemical Name: ZXH-3-26
CAS Number: 2243076-67-5
Molecular Formula: C₃₈H₃₇ClN₈O₇S
Molecular Weight: 785.27
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-06-01 18:07:14
Modify Date: 2024-01-14 14:07:07
ZXH-3-26 is a selective BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM[1].

Name	ZXH-3-26

Description	ZXH-3-26 is a selective BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4:5 nM (DC50, 5 hours of treatment)
In Vitro	ZXH-3-26 represents the first small molecule to allow pharmacologic targeting of BRD4 without significant inhibition or degradation of BRD2/3[1].
References	[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.

Molecular Formula	C₃₈H₃₇ClN₈O₇S
Molecular Weight	785.27

Hazard Codes	Xi