1215548-30-3

1215548-30-3 structure

Name: CFM 1571 hydrochloride
Chemical Name: CFM 1571 hydrochloride
CAS Number: 1215548-30-3
Molecular Formula: C₂₃H₂₉ClN₄O₃
Molecular Weight: 444.954
Catalog: Signaling Pathways GPCR/G Protein Guanylate Cyclase
Create Date: 2019-08-08 13:28:51
Modify Date: 2024-01-09 09:55:44
CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 (hydrochloride) (compound 32) has the potential for the research of cardiovascular and other diseases[1][2].

Name	CFM 1571 hydrochloride
Synonyms	1-Benzyl-3-[3-(dimethylamino)propoxy]-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide hydrochloride (1:1)

Description	CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 (hydrochloride) (compound 32) has the potential for the research of cardiovascular and other diseases[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase
Target	sGC[1][2]
In Vivo	Assessment of Pharmacokinetics (PK) profile of CFM 1571 (hydrochloride) (compound 32) in rat[1] . compd Cmax (ng/mL) AUC (ng/h/mL) tmax (h) F (%) 32b 6.4 61.1 2.7 12 b: dosed at 5 mg/kg po.
References	[1]. Selwood DL, et al. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem. 2001;44(1):78-93. [2]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5(9):755-768.