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1315378-73-4

1315378-73-4 structure
1315378-73-4 structure
  • Name: PDZ1 Domain inhibitor peptide
  • Chemical Name: PDZ1 Domain inhibitor peptide
  • CAS Number: 1315378-73-4
  • Molecular Formula: C38H61N9O11
  • Molecular Weight: 819.945
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2019-06-16 20:06:29
  • Modify Date: 2024-01-11 21:00:39
  • PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1].

Name PDZ1 Domain inhibitor peptide
Synonyms L-Valine, N-[[(2S,5S,14S)-14-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxohexyl]amino]-2-(1-hydroxyethyl)-3,8,15-trioxo-1,4,9-triazacyclopentadec-5-yl]carbonyl]-L-alanyl-
N-({(2S,5S,14S)-2-(1-Hydroxyethyl)-3,8,15-trioxo-14-[(L-tyrosyl-L-lysyl)amino]-1,4,9-triazacyclopentadecan-5-yl}carbonyl)-L-alanyl-L-valine
Description PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1].
Related Catalog
References

[1]. Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11(4):469-73.

Density 1.3±0.1 g/cm3
Boiling Point 1304.2±65.0 °C at 760 mmHg
Molecular Formula C38H61N9O11
Molecular Weight 819.945
Flash Point 742.5±34.3 °C
Exact Mass 819.449036
LogP -2.24
Appearance White lyophilised solid
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.597
Storage condition Desiccate at -20°C
Water Solubility Soluble to 1 mg/ml in 5% acetonitrile / H2O and to 4 mg/ml in DMSO