433238-84-7

433238-84-7 structure

Name: PP7
Chemical Name: PP7
CAS Number: 433238-84-7
Molecular Formula: C₁₈H₁₄Cl₂N₂O₃
Molecular Weight: 377.22
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2019-08-03 18:20:58
Modify Date: 2024-01-02 13:23:36
PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes[1].

Name	PP7

Description	PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
Target	IC50: 8.6 μM (PB1-PB2 interaction)[1]
References	[1]. Yuan S, et al. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface. Antiviral Res. 2017 Jan;137:58-66.

Molecular Formula	C₁₈H₁₄Cl₂N₂O₃
Molecular Weight	377.22