544681-96-1

544681-96-1 structure

Name: GATA4-IN-3
Chemical Name: GATA4-NKX2-5-IN-1
CAS Number: 544681-96-1
Molecular Formula: C₂₁H₂₃N₃O₂
Molecular Weight: 349.43
Catalog: Research Areas Cardiovascular Disease
Create Date: 2019-10-07 18:24:52
Modify Date: 2024-01-12 10:38:35
GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].

Name	GATA4-NKX2-5-IN-1

Description	GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	IC50: 3 μM (GATA4–NKX2-5)[1]
References	[1]. Välimäki MJ, et al. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem. 2017 Sep 28;60(18):7781-7798.

Molecular Formula	C₂₁H₂₃N₃O₂
Molecular Weight	349.43