1481641-08-0

1481641-08-0 structure
1481641-08-0 structure
  • Name: RIPK1-IN-4
  • Chemical Name: RIPK1-IN-4
  • CAS Number: 1481641-08-0
  • Molecular Formula: C23H23N5O2
  • Molecular Weight: 401.46
  • Catalog: Signaling Pathways Apoptosis RIP kinase
  • Create Date: 2019-10-07 19:18:52
  • Modify Date: 2024-02-05 19:12:16
  • RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].

Name RIPK1-IN-4
Description RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].
Related Catalog
Target

IC50: 16 nM (RIP1) and 10 nM (ADP-Glo)[1]

References

[1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.

Molecular Formula C23H23N5O2
Molecular Weight 401.46