1673571-51-1
1673571-51-1 structure
- Name: KAR-5585
- Chemical Name: Rodatristat ethyl
- CAS Number: 1673571-51-1
- Molecular Formula: C29H31ClF3N5O3
- Molecular Weight: 590.04
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tryptophan Hydroxylase
- Create Date: 2019-10-07 20:30:52
- Modify Date: 2024-01-08 18:57:46
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Rodatristat ethyl (KAR5585) is an orally active tryptophan hydroxylase 1 (TPH1) inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH)[1][2].
| Name | Rodatristat ethyl |
|---|
| Description | Rodatristat ethyl (KAR5585) is an orally active tryptophan hydroxylase 1 (TPH1) inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH)[1][2]. |
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| Related Catalog | |
| In Vivo | Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT)[1]. Animal Model: Male Sprague-Dawley rats (175-200 g)[1] Dosage: 100 mg/kg or 200 mg/kg Administration: Oral administration; once daily; for 28 days Result: Decreased serum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduced pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats. |
| References |
| Molecular Formula | C29H31ClF3N5O3 |
|---|---|
| Molecular Weight | 590.04 |