1182129-77-6

1182129-77-6 structure

Name: RU-302
Chemical Name: RU-302
CAS Number: 1182129-77-6
Molecular Formula: C₂₄H₂₄F₃N₃O₂S
Molecular Weight: 475.53
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK TAM Receptor
Create Date: 2019-10-09 14:11:29
Modify Date: 2024-01-11 09:44:48
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].

Name	RU-302

Description	RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor
Target	TAM, Axl[1]
References	[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.

Molecular Formula	C₂₄H₂₄F₃N₃O₂S
Molecular Weight	475.53

Hazard Codes	Xi