1809068-70-9

1809068-70-9 structure

Name: SMAP-2
Chemical Name: SMAP-2
CAS Number: 1809068-70-9
Molecular Formula: C₂₇H₂₇F₃N₂O₄S
Molecular Weight: 532.57
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2019-10-04 16:37:12
Modify Date: 2024-01-11 16:42:06
SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].

Name	SMAP-2

Description	SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Target	PP2A[1]
References	[1]. Sangodkar J, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 1;127(6):2081-2090.

Molecular Formula	C₂₇H₂₇F₃N₂O₄S
Molecular Weight	532.57