2247894-32-0
2247894-32-0 structure
- Name: SGC AAK1 1
- Chemical Name: SGC-AAK1-1
- CAS Number: 2247894-32-0
- Molecular Formula: C21H25N5O3S
- Molecular Weight: 427.52
- Catalog: Signaling Pathways Stem Cell/Wnt Wnt
- Create Date: 2019-12-08 09:08:54
- Modify Date: 2024-04-01 14:05:27
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SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].
| Name | SGC-AAK1-1 |
|---|
| Description | SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 270 nM (AAK1)[1]. Ki: 9 nM (AAK1)[1] |
| In Vitro | SGC-AAK1-1 (1.25 μM) significantly reduces phosphorylation of AP2M1 (T156) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells[1]. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription[1]. |
| References |
| Molecular Formula | C21H25N5O3S |
|---|---|
| Molecular Weight | 427.52 |