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2172617-16-0

2172617-16-0 structure
2172617-16-0 structure
  • Name: YKL-06-062
  • Chemical Name: YKL-06-062
  • CAS Number: 2172617-16-0
  • Molecular Formula: C31H39N7O
  • Molecular Weight: 525.69
  • Create Date: 2019-12-08 15:12:19
  • Modify Date: 2024-01-10 17:31:02
  • YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively. YKL-06-062 is the structural analog of YKL-06-062[1].

Name YKL-06-062
Description YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively. YKL-06-062 is the structural analog of YKL-06-062[1].
In Vitro YKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner[1]. RT-PCR[1] Cell Line: Human melanocyte cells, UACC62 melanoma cells Concentration: 0.0004 μM, 0.004 μM, 0.04 μM, 0.4 μM, 4 μM,8 μM,16 μM Incubation Time: 3 hours Result: Unregulated MITF mRNA expression.
References

[1]. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184.

Molecular Formula C31H39N7O
Molecular Weight 525.69