2368900-32-5
2368900-32-5 structure
- Name: CMLD012073
- Chemical Name: CMLD012073
- CAS Number: 2368900-32-5
- Molecular Formula: C30H30N2O7
- Molecular Weight: 530.57
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
- Create Date: 2019-12-08 15:56:19
- Modify Date: 2024-09-11 06:10:22
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CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1].
| Name | CMLD012073 |
|---|
| Description | CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1]. |
|---|---|
| Related Catalog | |
| Target |
eIF4A[1] |
| In Vitro | In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA[1]. |
| References |
| Molecular Formula | C30H30N2O7 |
|---|---|
| Molecular Weight | 530.57 |