Name | QO IIR |
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Synonyms | (E)-3-(3,4-Dihydroxy-2-nitrophenyl)-1-phenylprop-2-en-1-one |
Description | QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM; fully reverses the reserpine-induced catalepsy in vivo, demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD. |
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References | References 1. Rivas E, et al. Br J Pharmacol. 1999 Apr;126(7):1667-73. 2. Pérez RA, et al. Biochem Pharmacol. 1993 May 25;45(10):1973-81. View Related Products by Target COMT |
Molecular Formula | C15H11NO5 |
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Molecular Weight | 285.25 |
Exact Mass | 285.063722 |