1187451-19-9
1187451-19-9 structure
- Name: Omidenepag isopropyl
- Chemical Name: Omidenapag isopropyl
- CAS Number: 1187451-19-9
- Molecular Formula: C26H28N6O4S
- Molecular Weight: 520.603
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2020-01-11 21:58:50
- Modify Date: 2024-01-02 18:52:37
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Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. Other Indication Preregistration
| Name | Omidenapag isopropyl |
|---|---|
| Synonyms |
DE-117
Isopropyl N-[6-({[4-(1H-pyrazol-1-yl)benzyl](3-pyridinylsulfonyl)amino}methyl)-2-pyridinyl]glycinate G0G0H52U6K Omidenapag isopropyl Glycine, N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]-, 1-methylethyl ester OMIDENEPAG ISOPROPYL UNII-G0G0H52U6K |
| Description | Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. Other Indication Preregistration |
|---|---|
| Related Catalog | |
| Target |
EP2 |
| In Vivo | Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP change after drug administration was compared to the predosing baseline value established on day 1. Omidenepag isopropyl also shows significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist , with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models[1]. In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 709.9±70.0 °C at 760 mmHg |
| Molecular Formula | C26H28N6O4S |
| Molecular Weight | 520.603 |
| Flash Point | 383.1±35.7 °C |
| Exact Mass | 520.189270 |
| LogP | 3.26 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.641 |