1203479-63-3

1203479-63-3 structure

Name: SRTCX1002
Chemical Name: 2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide
CAS Number: 1203479-63-3
Molecular Formula: C₂₁H₁₉N₅O₂S
Molecular Weight: 405.473
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2020-01-11 12:01:57
Modify Date: 2023-01-16 09:50:39
SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.

Name	2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide
Synonyms	1H-Benzimidazole-7-carboxamide, 2-[3-(4-morpholinyl)phenyl]-N-2-thiazolyl- 2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide

Description	SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
References	References 1. Yang H, et al. PLoS One. 2012;7(9):e46364. 2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448. View Related Products by Target Sirtuin