1203479-63-3
1203479-63-3 structure
- Name: SRTCX1002
- Chemical Name: 2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide
- CAS Number: 1203479-63-3
- Molecular Formula: C21H19N5O2S
- Molecular Weight: 405.473
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2020-01-11 12:01:57
- Modify Date: 2024-10-11 21:23:26
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SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
| Name | 2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide |
|---|---|
| Synonyms |
1H-Benzimidazole-7-carboxamide, 2-[3-(4-morpholinyl)phenyl]-N-2-thiazolyl-
2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide |
| Description | SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner. |
|---|---|
| References | References 1. Yang H, et al. PLoS One. 2012;7(9):e46364. 2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448. View Related Products by Target Sirtuin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H19N5O2S |
| Molecular Weight | 405.473 |
| Exact Mass | 405.125946 |
| LogP | 2.73 |
| Index of Refraction | 1.732 |