1402612-58-1

1402612-58-1 structure

Name: KT-195
Chemical Name: [4-(4'-Methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
CAS Number: 1402612-58-1
Molecular Formula: C₂₇H₂₆N₄O₂
Molecular Weight: 438.521
Create Date: 2020-01-14 15:50:33
Modify Date: 2024-01-06 09:08:16
KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM; displays negligible activity against other serine hydrolases such as DAGLβ; induce a significant accumulation of 2-AG in Neuro2a cells; inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−; inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak.

Name	[4-(4'-Methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
Synonyms	Methanone, [4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- [4-(4'-Methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone

Description	KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM; displays negligible activity against other serine hydrolases such as DAGLβ; induce a significant accumulation of 2-AG in Neuro2a cells; inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−; inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak.
References	References 1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007. 2. Yun B, et al. J Biol Chem. 2014 Jan 17;289(3):1491-504. View Related Products by Target Other Targets