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  • DC Chemicals Limited
  • China
  • Product Name: KT-172
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1402612-56-9

1402612-56-9 structure
1402612-56-9 structure
  • Name: KT-172
  • Chemical Name: KT172
  • CAS Number: 1402612-56-9
  • Molecular Formula: C28H28N4O2
  • Molecular Weight: 452.547
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2020-01-11 17:42:00
  • Modify Date: 2024-02-08 10:32:45
  • KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM; displays selectivity over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11; disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages; possesses one remaining off-target ABHD6 (IC50=5 nM).

Name KT172
Synonyms (2-Benzylpiperidin-1-yl)(4-(2'-methoxy-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone
Cravatt Reagent
KT172
Methanone, [4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-
MFCD26960820
(2-Benzyl-1-piperidinyl)[4-(2'-methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl]methanone
[4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone
Description KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM; displays selectivity over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11; disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages; possesses one remaining off-target ABHD6 (IC50=5 nM).
References References 1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007. View Related Products by Target Diacylglycerol Lipase (DAGL)
Density 1.2±0.1 g/cm3
Boiling Point 636.1±47.0 °C at 760 mmHg
Molecular Formula C28H28N4O2
Molecular Weight 452.547
Flash Point 338.5±29.3 °C
Exact Mass 452.221222
LogP 4.89
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.641