1426916-02-0

1426916-02-0 structure

Name: ML298
Chemical Name: 3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide
CAS Number: 1426916-02-0
Molecular Formula: C₂₂H₂₃F₃N₄O₂
Molecular Weight: 432.439
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2020-01-19 23:38:04
Modify Date: 2024-04-03 13:05:01
ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM); decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile, making it an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments.

Name	3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide
Synonyms	3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-

Description	ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM); decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile, making it an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments.
References	References 1. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 2. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase

RIDADR	NONH for all modes of transport