1426916-02-0
1426916-02-0 structure
- Name: ML298
- Chemical Name: 3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide
- CAS Number: 1426916-02-0
- Molecular Formula: C22H23F3N4O2
- Molecular Weight: 432.439
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2020-01-19 23:38:04
- Modify Date: 2024-04-03 13:05:01
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ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM); decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile, making it an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments.
| Name | 3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide |
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| Synonyms |
3,4-Difluoro-N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl}benzamide
Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- |
| Description | ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM); decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile, making it an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments. |
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| References | References 1. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9. 2. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 650.5±55.0 °C at 760 mmHg |
| Molecular Formula | C22H23F3N4O2 |
| Molecular Weight | 432.439 |
| Flash Point | 347.2±31.5 °C |
| Exact Mass | 432.177307 |
| LogP | 1.70 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.620 |
| RIDADR | NONH for all modes of transport |
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