1582736-32-0

1582736-32-0 structure

Name: GPR39 modulator 7
Chemical Name: N-(5-((2-((((1r,4r)-4-((3-Cyanophenylsulfonamido)methyl)cyclohexyl)methyl)amino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)pentyl)acetamide
CAS Number: 1582736-32-0
Molecular Formula: C₃₁H₄₀N₈O₃S
Molecular Weight: 604.766
Create Date: 2020-01-13 08:34:51
Modify Date: 2024-02-04 16:09:11
GPR39 modulator 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.

Name	N-(5-((2-((((1r,4r)-4-((3-Cyanophenylsulfonamido)methyl)cyclohexyl)methyl)amino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)pentyl)acetamide
Synonyms	N-(5-{[2-({[trans-4-({[(3-Cyanophenyl)sulfonyl]amino}methyl)cyclohexyl]methyl}amino)-6-(2-pyridinyl)-4-pyrimidinyl]amino}pentyl)acetamide Acetamide, N-[5-[[2-[[[trans-4-[[[(3-cyanophenyl)sulfonyl]amino]methyl]cyclohexyl]methyl]amino]-6-(2-pyridinyl)-4-pyrimidinyl]amino]pentyl]- N-(5-((2-((((1r,4r)-4-((3-Cyanophenylsulfonamido)methyl)cyclohexyl)methyl)amino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)pentyl)acetamide

Description	GPR39 modulator 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.
References	References 1. Bassilana F, et al. Nat Chem Biol. 2014 May;10(5):343-9. View Related Products by Target GPR39