Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ROCHE ?-SECRETASE INHIBITIOR-1
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1172637-87-4

1172637-87-4 structure

Name: gamma-secretase modulator 1
Chemical Name: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
CAS Number: 1172637-87-4
Molecular Formula: C₂₄H₂₄N₄OS
Molecular Weight: 416.53900
Catalog: Signaling Pathways Neuronal Signaling γ-secretase
Create Date: 2018-12-04 20:41:57
Modify Date: 2024-01-08 16:09:43
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

Name	N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
Synonyms	[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-(4-phenyl-4,5,6,7-tetrahydrobenzothiazol-2-yl)amine gamma-secretase modulator 1

Description	γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> γ-secretase Signaling Pathways >> Stem Cell/Wnt >> γ-secretase Research Areas >> Neurological Disease
References	[1]. Baumann, Karlheinz; Flohr, Alexander; Preparation of 4,5,6,7-tetrahydrobenzothiazolyl- or 5,6,7,8-tetrahydroquinazolinylphenylamine derivatives as modulators for amyloid beta. PCT Int. Appl. (2009), 111pp. CODEN: PIXXD2 WO 2009087127 A1

Density	1.3
Molecular Formula	C₂₄H₂₄N₄OS
Molecular Weight	416.53900
Exact Mass	416.16700
PSA	83.44000
LogP	5.27950
Storage condition	2-8℃

958245-17-5

1172637-87-4

Literature: Luebbers, Thomas; Flohr, Alexander; Jolidon, Synese; Jacobsen, Helmut; Ozmen, Laurence; Baumann, Karlheinz; David-Pierson, Pascale Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6554 - 6558

1444-65-1

1172637-87-4

1009-36-5

1172637-87-4

Precursor 3
958245-17-5 1444-65-1 1009-36-5
DownStream 0

1172637-87-4	1093978-89-2
1431697-84-5	1353570-53-2
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2694817-84-8	2434630-29-0
2434630-30-3	2204249-82-9
2137895-18-0	2228347-43-9
1158522-08-7	2171738-35-3
940364-43-2	134104-43-1
2639455-43-7	131615-57-1
6906-52-1	930439-75-1