2101957-05-3

2101957-05-3 structure

Name: GNE-886
Chemical Name: 6-Allyl-N-{1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl}-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide
CAS Number: 2101957-05-3
Molecular Formula: C₂₈H₃₀N₆O₃
Molecular Weight: 498.576
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2020-01-12 10:07:50
Modify Date: 2024-01-09 16:13:59
GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.

Name	6-Allyl-N-{1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl}-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide
Synonyms	1H-Pyrrolo[2,3-c]pyridine-4-carboxamide, 6,7-dihydro-N-[1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl]-N-methyl-7-oxo-6-(2-propen-1-yl)- MFCD31556840 6-Allyl-N-{1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl}-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

Description	GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.
References	References 1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741. View Related Products by Target Bromodomain