503468-03-9
503468-03-9 structure
- Name: NU-7163
- Chemical Name: 2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one
- CAS Number: 503468-03-9
- Molecular Formula: C18H17NO3
- Molecular Weight: 295.332
- Create Date: 2020-01-11 19:51:50
- Modify Date: 2024-01-21 11:59:00
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A poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM; exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α; sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro.
| Name | 2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one |
|---|---|
| Synonyms |
2-(2-methylmorpholin-4-yl)-4H-benzo[h]chromen-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-(2-methyl-4-morpholinyl)- 2-(2-Methyl-4-morpholinyl)-4H-benzo[h]chromen-4-one 2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one |
| Description | A poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM; exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α; sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro. |
|---|---|
| References | References 1. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85. View Related Products by Target DNA-PK |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 461.3±45.0 °C at 760 mmHg |
| Molecular Formula | C18H17NO3 |
| Molecular Weight | 295.332 |
| Flash Point | 232.8±28.7 °C |
| Exact Mass | 295.120850 |
| LogP | 3.78 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.646 |