529507-84-4

529507-84-4 structure

Name: XIB-4035
Chemical Name: aminoquinol
CAS Number: 529507-84-4
Molecular Formula: C₂₆H₃₁Cl₂N₃
Molecular Weight: 456.450
Catalog: Research Areas Neurological Disease
Create Date: 2020-01-11 16:05:03
Modify Date: 2024-01-02 15:48:57
A nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1); concentration-dependently inhibits [(125)I]GDNF binding in Neuro-2A cells with IC50 of 10.4 uM; induces autophosphorylation of Ret protein, promotes neurite outgrowth in Neuro-2A cells, and induces Ret autophosphorylation in the Neuro-2A cells.

Name	aminoquinol
Synonyms	AMINOQUINOL, (R)- AMINOQUINOL, (S)- N4-{7-Chloro-2-[(E)-2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine N4-[7-Chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-1,4-pentanediamine aminoquinol MFCD00601670 UNII:CH1Y88E2AY 1,4-Pentanediamine, N4-[7-chloro-2-[(E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl- CH1Y88E2AY N4-{7-Chloro-2-[(E)-2-(2-chlorophenyl)vinyl]quinolin-4-yl}-N1,N1-diethylpentane-1,4-diamine N-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N-[4-(diethylamino)-1-methylbutyl]amine N-4-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N1,N1-diethyl-pentane-1,4-diamine XIB4035

Description	A nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1); concentration-dependently inhibits [(125)I]GDNF binding in Neuro-2A cells with IC50 of 10.4 uM; induces autophosphorylation of Ret protein, promotes neurite outgrowth in Neuro-2A cells, and induces Ret autophosphorylation in the Neuro-2A cells.
References	References 1. Hedstrom KL, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2325-30. 2. Tokugawa K, et al. Neurochem Int. 2003 Jan;42(1):81-6. 3. Höke A. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2060-1. View Related Products by Target Other Targets