667887-37-8

667887-37-8 structure

Name: Roxyl-WL
Chemical Name: 1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione
CAS Number: 667887-37-8
Molecular Formula: C₂₀H₁₄N₆O₂
Molecular Weight: 370.364
Create Date: 2020-01-20 10:25:56
Modify Date: 2024-01-20 13:21:22
Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.

Name	1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione
Synonyms	1,2,3-Triazolo[4,5-f][1,2,3]benzotriazole-4,8(1H,5H)-dione, 1,5-bis(phenylmethyl)- 1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione

Description	Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.
References	References 1. Xu G, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1089-1094. View Related Products by Target Indoleamine 2,3-Dioxygenase (IDO)