875863-22-2

875863-22-2 structure

Name: STING agonist C11
Chemical Name: N-(Methylcarbamoyl)-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetamide
CAS Number: 875863-22-2
Molecular Formula: C₁₉H₁₈N₄O₃S
Molecular Weight: 382.436
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2020-01-12 12:02:26
Modify Date: 2024-07-18 02:51:07
STING agonist C11 is a novel cell-permeable STING agonist that activates IFN-dependent signaling processes and induces IFN secretion from human cells; induces transcription and translation of interferon-dependent antiviral genes, induces canonical IRF3 phosphorylation and ISG transcription in a manner that requires STING but not MAVS or TRIF; potently blocks replication of multiple emerging Alphavirus types including Chikungunya, Ross River, Mayaro, and O'nyong'nyong viruses.

Name	N-(Methylcarbamoyl)-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetamide
Synonyms	Benzeneacetamide, N-[(methylamino)carbonyl]-α-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]- N-(Methylcarbamoyl)-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetamide

Description	STING agonist C11 is a novel cell-permeable STING agonist that activates IFN-dependent signaling processes and induces IFN secretion from human cells; induces transcription and translation of interferon-dependent antiviral genes, induces canonical IRF3 phosphorylation and ISG transcription in a manner that requires STING but not MAVS or TRIF; potently blocks replication of multiple emerging Alphavirus types including Chikungunya, Ross River, Mayaro, and O'nyong'nyong viruses.
References	References 1. Gall B, et al. J Virol. 2017 Dec 20. pii: JVI.01913-17. View Related Products by Target STING