1119503-63-7

1119503-63-7 structure

Name: JNc-440
Chemical Name: N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide
CAS Number: 1119503-63-7
Molecular Formula: C₂₆H₂₄N₄O₃
Molecular Weight: 440.494
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2020-01-11 20:14:24
Modify Date: 2024-01-03 12:11:44
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.

Name	N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide
Synonyms	2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-4-hydroxy- N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide

Description	JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.
References	References 1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725. View Related Products by Target TRP Channel