1211231-76-3

1211231-76-3 structure

Name: NKTR-181
Chemical Name: oxycodegol
CAS Number: 1211231-76-3
Molecular Formula: C₃₁H₄₉NO₁₀
Molecular Weight: 595.721
Create Date: 2020-01-12 19:16:33
Modify Date: 2024-01-04 17:23:53
A novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold); demonstrates maximum analgesic activity comparable to that of oxycodone in hot-plate latency and acetic-acid writhing models, reduces its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists. Pain Phase 3 Clinical

Name	oxycodegol
Synonyms	(5α,6α)-6-(2,5,8,11,14,17-Hexaoxanonadecan-19-yloxy)-3-methoxy-17-methyl-4,5-epoxymorphinan-14-ol Morphinan-14-ol, 4,5-epoxy-6-(3,6,9,12,15,18-hexaoxanonadec-1-yloxy)-3-methoxy-17-methyl-, (5α,6α)- oxycodegol

Description	A novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold); demonstrates maximum analgesic activity comparable to that of oxycodone in hot-plate latency and acetic-acid writhing models, reduces its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists. Pain Phase 3 Clinical
References	References 1. Miyazaki T, et al. J Pharmacol Exp Ther. 2017 Oct;363(1):104-113. 2. Webster L, et al. Pain Med. 2017 Mar 10. doi: 10.1093/pm/pnw344. View Related Products by Target Opioid Receptor Pain