1314944-07-4

1314944-07-4 structure

Name: Imigliptin dihydrochloride
Chemical Name: Imigliptin
CAS Number: 1314944-07-4
Molecular Formula: C₂₁H₂₆Cl₂N₆O
Molecular Weight: 376.455
Create Date: 2020-01-11 18:27:50
Modify Date: 2024-01-18 14:32:27
A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM; displays no activity against DPP-8 and DPP-9 (IC50>100 uM); shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell. Diabetes Phase 2 Clinical

Name	Imigliptin
Synonyms	2-({7-[(3R)-3-Amino-1-piperidinyl]-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl}methyl)benzonitrile Benzonitrile, 2-[[7-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-3,5-dimethyl-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl]methyl]- Imigliptin

Description	A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM; displays no activity against DPP-8 and DPP-9 (IC50>100 uM); shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell. Diabetes Phase 2 Clinical
References	References 1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. 2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82. View Related Products by Target Dipeptidyl Peptidase (DPP) Diabetes