332108-65-3
332108-65-3 structure
- Name: ABMA
- Chemical Name: N-(5-Bromo-2-methoxybenzyl)-1-adamantanamine
- CAS Number: 332108-65-3
- Molecular Formula: C18H24BrNO
- Molecular Weight: 350.293
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-01-11 12:15:06
- Modify Date: 2024-01-11 20:35:55
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ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite; protects mice from nasal instillation of an LD90 of ricin; provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles.
| Name | N-(5-Bromo-2-methoxybenzyl)-1-adamantanamine |
|---|---|
| Synonyms |
Adamantan-1-yl-(5-bromo-2-methoxy-benzyl)-amine
N-(5-Bromo-2-methoxybenzyl)-1-adamantanamine N-(5-Bromo-2-methoxybenzyl)adamantan-1-amine Tricyclo[3.3.1.13,7]decan-1-amine, N-[(5-bromo-2-methoxyphenyl)methyl]- |
| Description | ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite; protects mice from nasal instillation of an LD90 of ricin; provokes Rab7-positive late endosomal compartment accumulation in mammalian cells without affecting other organelles. |
|---|---|
| Related Catalog | |
| Target |
Intracellular bacteria[1] Viruses[1] Parasite[1] |
| In Vitro | ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3 µM), Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3 µM), rabies (EC50 of 19.4 µM), dengue-4 virus ( EC50 of 8.2 µM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC50 of 7.1 µM) at micromolar level[1]. In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days[1]. |
| In Vivo | ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD90 of ricin[1]. Animal Model: Pathogen-free female BALB/c mice (6 week-old) with ricin[1] Dosage: 2 mg/kg, 20 mg/kg, 200 mg/kg Administration: Intraperitoneal injection Result: A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 428.2±30.0 °C at 760 mmHg |
| Molecular Formula | C18H24BrNO |
| Molecular Weight | 350.293 |
| Flash Point | 212.8±24.6 °C |
| Exact Mass | 349.104126 |
| LogP | 5.35 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.606 |