351986-85-1
351986-85-1 structure
- Name: Vacuolin-1
- Chemical Name: 4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(4-morpholinyl)-N,N-diphenyl-1,3,5-triazin-2-amine
- CAS Number: 351986-85-1
- Molecular Formula: C26H24IN7O
- Molecular Weight: 577.419
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2020-01-12 00:03:07
- Modify Date: 2024-02-05 18:31:30
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A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A; blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles.
| Name | 4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(4-morpholinyl)-N,N-diphenyl-1,3,5-triazin-2-amine |
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| Synonyms |
4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(morpholin-4-yl)-N,N-diphenyl-1,3,5-triazin-2-amine
4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(4-morpholinyl)-N,N-diphenyl-1,3,5-triazin-2-amine Benzaldehyde, 3-iodo-, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone |
| Description | A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A; blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles. |
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| References | References 1. Cerny J, et al. EMBO Rep. 2004 Sep;5(9):883-8. 2. Shaik GM, et al. Cell Signal. 2009 Aug;21(8):1337-45. 3. Lu Y, et al. Autophagy. 2014;10(11):1895-905. 4. Sano O, et al. FEBS Lett. 2016 Jun;590(11):1576-85. View Related Products by Target Autophagy |
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 719.7±70.0 °C at 760 mmHg |
| Molecular Formula | C26H24IN7O |
| Molecular Weight | 577.419 |
| Flash Point | 389.1±35.7 °C |
| Exact Mass | 577.108704 |
| LogP | 4.41 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.706 |
| Hazard Codes | Xi |
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