862975-18-6
862975-18-6 structure
- Name: MLS-0437605
- Chemical Name: 4-Fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1,3-benzothiazol-2-amine
- CAS Number: 862975-18-6
- Molecular Formula: C16H11FN4O2S
- Molecular Weight: 342.348
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-01-11 18:49:50
- Modify Date: 2024-04-03 11:07:55
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MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.); specifically inhibits collagen- and C-type lectin-like receptor 2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells.
| Name | 4-Fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1,3-benzothiazol-2-amine |
|---|---|
| Synonyms |
2-Benzothiazolamine, 4-fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-
4-Fluoro-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1,3-benzothiazol-2-amine |
| Description | MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.); specifically inhibits collagen- and C-type lectin-like receptor 2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells. |
|---|---|
| References | References 1. Musumeci L, et al. Circulation. 2015 Feb 17;131(7):656-68. View Related Products by Target Protein Phosphatase/PTP |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 519.0±56.0 °C at 760 mmHg |
| Molecular Formula | C16H11FN4O2S |
| Molecular Weight | 342.348 |
| Flash Point | 267.7±31.8 °C |
| Exact Mass | 342.058685 |
| LogP | 4.57 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.689 |