881970-80-5

881970-80-5 structure

Name: iMDK
Chemical Name: 3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one
CAS Number: 881970-80-5
Molecular Formula: C₂₁H₁₃FN₂O₂S
Molecular Weight: 376.404
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2020-01-11 23:49:52
Modify Date: 2024-01-09 10:44:46
iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF; inhibits the cell growth of MDK-positive H441 lung adenocarcinoma cells that harbor an oncogenic KRAS mutation and H520 squamous cell lung cancer cells, inhibits PI3K pathway and induces apoptosis; significantly inhibits tumor growth in a xenograft mouse model in vivo.

Name	3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one
Synonyms	3-[2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one 2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]- MFCD07528492

Description	iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF; inhibits the cell growth of MDK-positive H441 lung adenocarcinoma cells that harbor an oncogenic KRAS mutation and H520 squamous cell lung cancer cells, inhibits PI3K pathway and induces apoptosis; significantly inhibits tumor growth in a xenograft mouse model in vivo.
References	References 1. Hao H, et al. PLoS One. 2013 Aug 16;8(8):e71093. 2. Ishida N, et al. Exp Cell Res. 2015 Jul 15;335(2):197-206. 3. Masui M, et al. Anticancer Res. 2016 Jun;36(6):2775-81. View Related Products by Target Midkine

Hazard Codes	Xi