903591-53-7

903591-53-7 structure

Name: AMG1
Chemical Name: N-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl}-2,6-difluorobenzamide
CAS Number: 903591-53-7
Molecular Formula: C₁₈H₉ClF₅N₃O
Molecular Weight: 413.729
Create Date: 2020-01-11 08:39:51
Modify Date: 2024-01-11 07:09:20
A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.

Name	N-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl}-2,6-difluorobenzamide
Synonyms	MFCD27924112 Benzamide, N-[5-[2-chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl]-2,6-difluoro- N-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl}-2,6-difluorobenzamide

Description	A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.
References	References 1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85. View Related Products by Target Calcium Channel