1413405-33-0
1413405-33-0 structure
- Name: LSP4–2022
- Chemical Name: LSP4–2022
- CAS Number: 1413405-33-0
- Molecular Formula: C13H18NO8P
- Molecular Weight: 347.26
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2020-01-12 07:58:49
- Modify Date: 2024-04-03 07:27:15
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LSP4–2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays; displays >100-fold selectivity over mGlu7 and mGlu8 (IC50=11.6 and 29.2 uM), no activity at the group I and -II mGlu receptors (EC50>100 uM); inhibits neurotransmission in cerebellar slices from mice, and possesses antiparkinsonian properties in a haloperidol-induced catalepsy test.
| Name | LSP4–2022 |
|---|
| Description | LSP4–2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays; displays >100-fold selectivity over mGlu7 and mGlu8 (IC50=11.6 and 29.2 uM), no activity at the group I and -II mGlu receptors (EC50>100 uM); inhibits neurotransmission in cerebellar slices from mice, and possesses antiparkinsonian properties in a haloperidol-induced catalepsy test. |
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| References | References 1. Goudet C, et al. FASEB J. 2012 Apr;26(4):1682-93. 2. Vilar B, et al. J Neurosci. 2013 Nov 27;33(48):18951-65. 3. Podkowa K, et al. Neuropharmacology. 2015 Oct;97:338-45. View Related Products by Target mGluR |
| Molecular Formula | C13H18NO8P |
|---|---|
| Molecular Weight | 347.26 |