1353749-74-2
1353749-74-2 structure
- Name: CSRM617 hydrochloride
- Chemical Name: CSRM617 hydrochloride
- CAS Number: 1353749-74-2
- Molecular Formula: C10H14ClN3O5
- Molecular Weight: 291.688
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 05:01:33
- Modify Date: 2024-01-20 20:28:37
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CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly; inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2; significantly downregulates PEG10 protein levels in tumors from mice treated with CSRM617, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.
| Name | CSRM617 hydrochloride |
|---|
| Description | CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly; inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2; significantly downregulates PEG10 protein levels in tumors from mice treated with CSRM617, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice. |
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| References | References 1. Rotinen M, et al. Nat Med. 2018 Dec;24(12):1887-1898. View Related Products by Target Other Targets |
| Molecular Formula | C10H14ClN3O5 |
|---|---|
| Molecular Weight | 291.688 |